Furthermore, the level of synaptic loss in the post-mortem brain correlates with pre-mortem cognitive function in individuals with mild cognitive impairment or early Alzheimer's disease. Evidence suggests that NMDA receptors are central to the synaptic dysfunction observed in Alzheimer's disease. Overstimulation of NMDA receptors is thought to lead to a series of cascade events that culminate in synaptic dysfunction and apoptosis. Over the past decade, several proteins have been proposed as possible biomarkers of synaptic damage, and the most studied synaptic proteins are neurogranin, synaptosome-associated protein 25 (SNAP-25), synaptotagmin.
Other synaptic proteins are emerging. Finally, a PET tracer binding vesicular synaptic glycoprotein 2A (SV2) has recently been developed, which can be used to quantify synaptic Spain phone number list density in vivo. However, there is currently no consensus on the use of these synaptic biomarkers and thus further studies are needed. Our Research Topic aims to raise the research discussion on the relevance of synaptic biomarkers in Alzheimer’s disease and related dementias and improve our understanding of the early pathophysiological events involved in these diseases.
A from the preclinical and clinical research regarding the identification of synaptic biomarkers which may ultimately contribute to solving the current need for biomarkers with diagnostic and prognostic value for Alzheimer’s disease and related dementias. We welcome any type of manuscript supported by the journal, including original research articles, brief research articles, case reports, reviews, mini-reviews, and meta-analyses, concerning, but not limited to: - the study of the pathophysiology of synaptic disruption in Alzheimer's disease and related dementias - preclinical models of.